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In technical terms, Namenda is an N-methyl-D-aspartate (NMDA) antagonist that regulates the activity of in the brain.

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Namenda was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer's disease, vascular dementia) patients (940 patients treated with Namenda and 922 patients treated with placebo) for a treatment period up to 28 weeks.

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